Innate Immunity to Enteric Hepatitis Viruses
نویسندگان
چکیده
منابع مشابه
Enteric hepatitis viruses
The term “hepatitis viruses” refers to a diverse group of viruses all of which have the human liver as the primary target of replication and give rise to hepatitis or inflammation of the liver. Their replication may result in mass destruction of liver cells. Consequences include failure of the liver to fulfil basic functions such as removal of bilirubin from the circulatory blood system. Biliru...
متن کاملEnteric hepatitis viruses
Hepatitis viruses are infectious agents that can infect liver and cause inflammation. The infection triggers immune response against infected cells that leads to the destruction of hepatic cells. This destruction has two consequences: leaking ALT and AST liver enzymes which increases during the course of disease and accumulation of bilirubin- a red pigmented compound released from dead red cell...
متن کاملEnteric Hepatitis Viruses
Background The term ‘‘jaundice’’ was used as early as in the ancient Greece when Hippocrates described an illness probably corresponding to a viral hepatitis. However, it was not until the beginning of the twentieth century AU :1 when a form of hepatitis was associated to an infectious disease occurring in epidemics and the term ‘‘infectious hepatitis’’ was established. Later on in the early 19...
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Host cells sense viral infection through pattern recognition receptors (PRRs), which detect pathogen-associated molecular patterns (PAMPs) and stimulate an innate immune response. PRRs are localized to several different cellular compartments and are stimulated by viral proteins and nucleic acids. PRR activation initiates signal transduction events that ultimately result in an inflammatory respo...
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Avian influenza virus infections in the human population are rare due to their inefficient direct human-to-human transmission. However, when humans are infected, a strong inflammatory response is usually induced, characterized by elevated levels of cytokines and chemokines in serum, believed to be important in the severe pathogenesis that develops in a high proportion of these patients. Extensi...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Medicine
سال: 2018
ISSN: 2157-1422
DOI: 10.1101/cshperspect.a033464